Ovarian Cancer

Ovarian cancer is the uncontrolled growth of abnormal cells in the ovaries, the female reproductive organs that produce eggs. Ovarian cancer cells come from one of three areas in the ovary. Cancer cells forming in the surface layer of the ovary (epithelial carcinoma) are the most common. Cancer cells forming from the egg-producing cells (germ cell tumors) and from within the supportive tissues around the ovaries (stromal tumors) are less common.

The disease often does not cause any symptoms until it has spread beyond the ovaries, the late stage of ovarian cancer. It is difficult for a physician to detect ovarian cancer during a pelvic exam before this late stage. This helps explain why ovarian cancer leads to death more often than some other cancers. Ovarian cancer accounts for more deaths than any other cancer of the female reproductive system. The American Cancer Society estimates that 15,310 women were expected to die from ovarian cancer in the United States during 2006, according to their latest statistics.

Symptoms of ovarian cancer may be mild and imitate less serious problems even though the disease has spread to other organs. Symptoms can be vague and include frequent urination and bloating. For these reasons, about 75% of ovarian cancer cases aren't identified until the later, more dangerous, stages of the disease. Researchers are trying to develop screening tests to detect ovarian cancer in its early stage because it's more likely the disease can be cured or controlled when it is treated early.

The exact causes of ovarian cancer are unknown, but a number of risk factors have been identified. The disease has a strong genetic (inherited) component, and women who have had a first-degree relative (sister, mother or daughter) diagnosed with ovarian cancer are at a high risk of developing the disease, as are women who have a relative who has had breast or colon cancer. The likelihood of developing ovarian cancer also increases with age. Most ovarian cancers occur in women over age 50, and the highest risk is in women over 60. Women who have never had children are more likely to develop ovarian cancer.

Ovarian cancer accounts for 4% of all cancers in women. An estimated 20,180 new cases of ovarian cancer are expected to be diagnosed in the United States during 2006, according to the latest statistics.

Ovarian cancer usually doesn't cause obvious symptoms until late in its development, and, even then, the symptoms can be mistaken as signs of a minor disorder. Symptoms of ovarian cancer can include:

Occasionally, a doctor may find signs of early stage ovarian cancer, such as a firm, enlarged ovary when abnormal cells are confined to the ovary. A pelvic ultrasound may help diagnose the disease at an early stage. However, the ovaries often appear normal during early stages of ovarian cancer.

Computed tomography (CT) or magnetic resonance imaging (MRI) also can be used to identify misshapen or enlarged ovaries and other features that may point to or strongly suggest the presence of cancerous changes.

Blood tests can help confirm ovarian cancer by identifying high blood levels of CA-125, a protein commonly found in elevated levels in women who have ovarian cancer. The usefulness of this test is limited, however, because CA-125 can be elevated in many conditions that are not cancerous. The only way to be certain that cancer is present is to obtain a sample of ovarian tissue and have it examined for cancerous changes.

Women who take birth control pills have half the risk of developing ovarian cancer, possibly because these drugs prevent ovulation. The protective effect of the Pill is greatest in women who use it for 4 or more years. It is thought that breastfeeding, which also reduces the number of times a woman ovulates, can reduce the risk of ovarian cancer. Reducing the amount of fat in the diet also is thought to help reduce the risk of developing ovarian cancer.

Surgery is the usual treatment for ovarian cancer. In most cases, the ovaries, the fallopian tubes, the uterus and the cervix are removed, as well as the thin tissue covering the stomach and intestine (called the omentum) and surrounding lymph nodes.

Chemotherapy also may be necessary to kill remaining cancer cells. Radiation therapy is used less often. Both treatments also kill healthy cells, which can cause side effects, depending on the type, route, total dose and length of use. Possible side effects include fever, chills, rash, difficulty breathing, nausea, vomiting, diarrhea, anemia, fatigue, irregular heart rate patterns, clotting disorders, blood pressure changes, phlebitis, nerve damage, muscle weakness and pain.

It is important to check with a doctor if you notice any of the following symptoms:

Remember, the symptoms of ovarian cancer are vague and often mimic other less serious problems. It is even more important to have regular pelvic exams, and to be particularly wary of these symptoms if you are at high risk of ovarian cancer. Women at high risk of developing ovarian cancer include those who:

The likelihood of surviving ovarian cancer depends on how far it has spread when treatment begins. If ovarian cancer is identified and treated before it spreads beyond the ovary, the five-year survival rate is 95%. Only 25% of all ovarian cancers are found at this early stage.

About 78% of all patients with ovarian cancer survive one year after diagnosis. More than 50% survive longer than five years after diagnosis. In general, older women with ovarian cancer tend to have a poorer outlook than younger women.

National Ovarian Cancer Coalition, Inc.
500 NE, Suite 14
Spanish River Blvd.
Boca Raton, FL 33431
Phone: (561) 393-0005
Toll-Free: (888) 682-7426
Fax: (561) 393-7275
E-Mail: NOCC@aovarian.org
http:.www.ovarian.org/

American Cancer Society (ACS)
1599 Clifton Rd., NE
Atlanta, GA 30329-4251
Toll-Free: (800) 227-2345
http://www.cancer.org/

National Cancer Institute (NCI)
Building 31, Room 10A0331
Center Dr., MSC 2580
Bethesda, MD 20892-2580
Phone: (301) 435-3848
Toll-Free: (800) 422-6237
http://www.nci.nih.gov/

National Women's Health Information Center (NWHIC)
8550 Arlington Blvd.,
Suite 300
Fairfax, VA 22031
Toll-Free: (800) 994-9662
Fax: (703) 560-6598
TTY: (888) 220-5446
http://www.4woman.org/